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UA College of Pharmacy
Nearly every pharmacy and hospital in the U.S. relies on drug warning systems, and most physicians soon will, too. Yet such systems still have some weaknesses, which UA pharmacists are working to address.
For the first time, experts from a broad spectrum of fields have come together to begin to address a widely recognized and potentially dangerous weakness of drug warning systems, which are used now by nearly every pharmacy and hospital in the United States.
Soon, such systems also will be used by most physicians.
DDI alert systems warn health-care professionals of potentially dangerous interactions between two or more drugs prescribed for the same patient.
The systems are so sensitive, however, that they send alerts for drug combinations that have a very low probability of causing problems. This results in thousands of alerts being displayed per week at busy health-care facilities, which leads to "alert fatigue" in prescribers and pharmacists.
To combat alert fatigue, many health-care workers end up ignoring or overriding alerts. Studies have found up to a 90 percent override rate.
"This is a potentially catastrophic situation for patients taking multiple medications," said Malone, who is an expert in drug-drug interactions.
"It is not an easy problem to solve. There are so many factors that go into designing, implementing and using these sophisticated systems," Malone said. "We needed to bring together everyone involved: leaders from academia, clinical practice, government agencies, industry and international organizations."
To help those stakeholders collaborate, Malone and his team hosted an invitational conference of experts in DDI clinical decision support systems at the United States Pharmacopeia Convention Headquarters in Rockville, Md., in May. The meeting was one step in the effort, known as the Drug-Drug Interaction Clinical Decision Support Conference Series, to develop an ongoing, structured process to improve the quality of DDI alerting systems.
Participating in the conference were representatives from the Food and Drug Administration; the Office of the National Coordinator for Health Information Technology; the Agency for Healthcare Research and Quality; the RAND Corporation; drug knowledge database vendors Wolters Kluwer, Epocrates, Lexicomp and First DataBank; CDS software companies Epic and Cerner; the Pharmacy Quality Alliance and the American Society of Health-System Pharmacists.
"Drug-drug interactions represent an important cause of harm, and because providers in the U.S. are rapidly adopting electronic health records, it will be much easier to prevent them," said David Bates, professor of medicine at Boston's Brigham and Women's Hospital and Harvard Medical School.
"But it is critical that we get the settings right – many organizations have displayed too many interactions, and the really serious ones often look the same as some that are not very important in today's systems," said Bates, who participated in the May conference. "At the conference, we talked about how to approach these issues, which will be central to getting value from electronic records."
Standards are one of the aims of the Drug-Drug Interaction Clinical Decision Support Conference Series. The goals of the series are to:
Participants appreciated the collaborative nature of the May meeting.
"An old African proverb states: 'If you want to go fast, go alone. If you want to go far, go together,'" said Raymond Chan of Sentara Healthcare, a nonprofit organization that operates facilities in Virginia and North Carolina.
"This conference definitely brought together many of the brightest minds in CDS design and utilization, ultimately shooting for shifting the bar up," Chan also said.
The Drug-Drug Interaction Clinical Decision Support Conference Series will include more working meetings through 2013. Malone's goal is to have recommendations and guidelines for improving DDI alert systems ready to distribute for comments and feedback by early 2014.
UA College of Pharmacy